Evidence That Drives Better Health Decisions.
In-depth research reviews, clinical insights, and data-driven analysis on supplements, healthspan, and healthy aging.
Explore What Matters Most
Cognitive Health
Memory, focus, mood, and brain aging.
Energy & Longevity
Cellular energy, NAD+, mitochondria, and longevity.
Immune Health
Immune function, resilience, and healthy aging.
Joints & Mobility
Cartilage, joint comfort, and mobility support.
Gut Health
Microbiome balance, digestion, and gut barrier.
Sleep & Stress
Sleep quality, stress response, and recovery.
Hormonal & Metabolic
Hormone balance, blood sugar, and metabolism.
Skin & Anti-Aging
Collagen, elasticity, and healthy aging.
Heart & Circulation
Cardiovascular health, blood flow, and lipids.
Longevity Pathways
Cellular aging, resilience, and healthspan.
New Evidence. New Insights.
Supplement Evidence Density Map 2026
Original HAA data audit: 22.2% of 2,187 cleaned supplement-goal pairings had zero mapped published RCTs.
EPA vs DHA: Differential Effects on Cardiometabolic Health
A comprehensive review of how EPA and DHA affect inflammation, lipids, endothelial function, and cardiometabolic outcomes.
NAD+ Boosters and Healthy Aging: An Updated Review
Examining NMN, NR, and related compounds for NAD+ elevation, clinical evidence, and safety.
Creatine for Brain, Muscle, and Healthy Aging
Beyond performance: emerging research on creatine's role in cognition, aging, and overall healthspan.
Evidence, Safety & Policy Explainers
GLP-1 nutrient gaps: what reduced intake can miss
How reduced intake on a GLP-1 can create shortfalls in B12, iron, calcium, vitamin D, and magnesium, and when testing is worth discussing with your doctor.
Managing GLP-1 side effects: nausea, constipation, fatigue, and muscle loss
Practical, physician-anchored ways to manage the four most common GLP-1 side effects: nausea, constipation, fatigue, and muscle loss.
Living well on GLP-1: the basics that matter more than any supplement
A practical, physician-anchored guide to protein targets, strength training, hydration, and meal size while taking a GLP-1 medication.
Stopping a GLP-1: what the evidence says about plateaus and weight regain
What clinical trials show about plateaus and weight regain after stopping a GLP-1 medication, framed around the decision belonging with your prescriber.
What to eat on a GLP-1: making small meals count
How to build a satiety-first plate on a GLP-1 medication: protein quality, fiber, electrolytes, and small-meal patterns, with physician-anchored framing.
Supplement Evidence Density Map 2026
22.2% of 2,187 cleaned supplement-goal pairings in HAA's evidence matrix had zero published RCTs. Download the CSV and methods.
FDA peptide rules in 2026: BPC-157, TB-500, legal status, and PCAC review
Plain-English FDA peptide status for BPC-157, TB-500, legal-status questions, withdrawn nominations, safety-risk language, and the July 2026 PCAC review.
FDA supplement claims explained: what brands can and cannot imply
Plain-English guide to supplement claims: health claims, structure/function claims, FDA disclaimers, disease-treatment wording, and FTC substantiation.
How to read a supplement label before you buy
Learn how to read a Supplement Facts label: serving size, active dose, ingredient form, proprietary blends, warnings, claims, and quality seals.
How to read supplement evidence without getting fooled
A practical guide to supplement evidence: what RCTs, meta-analyses, observational studies, and mechanism data can and cannot prove.
Third-party testing for supplements: what the badges actually mean
What supplement quality seals mean: USP Verified, NSF Certified for Sport, Informed Sport, COAs, GMP, contaminants, banned substances, and limits.
ApoB vs LDL cholesterol: what each marker can and cannot tell you
A cautious guide to ApoB, LDL-C, non-HDL-C, and cardiovascular risk context for healthy-aging readers.
BPC-157 FDA status: approval, legal status, safety risks, athlete ban
Is BPC-157 FDA-approved or legal in the US? FDA has not approved it for wellness use, flags safety concerns, and USADA lists it under WADA S0.
Creatine and GLP-1 muscle loss: plausible support, not proven treatment
A cautious evidence guide to creatine, protein, resistance training, and lean-mass preservation during GLP-1 weight loss.
Fasting insulin and metabolic health: useful signal, not a diagnosis by itself
A careful guide to fasting insulin, insulin resistance, HOMA-IR, glucose, A1c, and why interpretation needs clinical context.
Homocysteine and methylation: what the marker means, and what it does not prove
A careful guide to homocysteine, folate, vitamin B12, vitamin B6, methylation, cardiovascular context, and supplement limits.
hs-CRP and inflammation: useful context, not a supplement scorecard
A careful guide to hs-CRP, CRP, inflammation, cardiovascular-risk context, and supplement-claim limits.
Menopause supplement safety: useful questions before buying anything
A safety-first guide to menopause supplements, black cohosh, soy isoflavones, DHEA, magnesium, sleep, hot flashes, and clinician care.
Protein after 40: muscle preservation starts before the shake
A practical evidence guide to protein, resistance training, muscle preservation, and supplement claim limits after 40.
Sleep after 40: what supplements can help with, and what they can miss
A careful guide to sleep changes after 40, melatonin, magnesium, glycine, L-theanine, insomnia, sleep apnea, and when to seek care.
TB-500 FDA status: LKKTETQ fragment, no human exposure data, WADA ban
Is TB-500 FDA-approved or legal to use? FDA cites no human exposure data for the LKKTETQ fragment, and WADA prohibits thymosin-beta4 derivatives.
American Heart Association Omega-3 Recommendations in 2026 — What the Science Advisory Says
What the American Heart Association advises: fatty fish twice a week, OTC fish oil, and 4g/day prescription EPA+DHA for high triglycerides.
Peptide safety: side effects, FDA risks, and human evidence
Are peptides safe? Review FDA concerns about immunogenicity, impurities, contamination, route-specific risk, and missing long-term human safety data.
Peptides vs supplements: what is the difference?
Peptides span four legal categories — approved drug to research chemical. Understanding which category applies changes what safety data exists.
Supplements While on GLP-1 Medications: A Complete Guide to Ozempic, Wegovy, Mounjaro, and Zepbound
8 key supplements for GLP-1 users: B12 form specificity, magnesium glycinate, D3+K2, omega-3, creatine — per-drug dosing tables and interaction flags.
Rigor. Transparency. Independence.
Comprehensive Search
Across databases
Evidence Evaluation
Quality and bias
Clinical Context
Real-world relevance
Safety First
Interactions and dosing
Expert Review
No brand influence
Stay Current with New Research
We add new research reviews every week. Get the latest evidence straight to your inbox.
Research Glossary
Understand key terms, study designs, and statistical concepts.
Last updated May 16, 2026 · New research added weekly