Because insulin resistance is a common feature for many people with PMOS, several supplements have been studied for metabolic and hormonal markers. The evidence varies a great deal by supplement and by symptom, and no supplement is a substitute for medical care.
Berberine is one of the more-studied examples: a randomized trial comparing it with metformin in women with PCOS reported broadly similar metabolic effects, and a later systematic review and meta-analysis pooled trials examining its effect on metabolic and reproductive measures. Evidence like this is promising for specific markers but is not the same as a proven treatment, and findings differ across supplements.
We do not give individual supplement recommendations on this page. For a symptom-by-symptom breakdown — insulin resistance, cycle regularity, acne and androgens, hair thinning, and more — see our PMOS/PCOS supplement hub and the individual supplement pages, each of which is reviewed by a registered dietitian and carries its own dosing and safety detail. Always confirm any supplement with the clinician managing your care.