2 supplements compared

Best Supplements for Migraine Prevention

Adults with episodic migraine seeking evidence-based prevention, those on standard preventives wanting adjunctive support, and adults whose neurologist has discussed CoQ10

Supplements compared

Reviewed

Evidence-led rankings

Clinical still life for Migraine Prevention supplement rankings

Evidence graded

Clinical relevance

Safety reviewed

Risks and interactions

Dosing checked

Evidence-based ranges

No medical claims

Research only

Updated regularly

New evidence tracked

Written by Editorial Team·Medically reviewed by Angelique Nicole R. Villegas, RND

Our top picks for migraine prevention

Supplement Comparisons

Which Supplement Is Best for Migraine Prevention?

CoQ10

Moderate Evidence

The American Headache Society gives CoQ10 Level B evidence for migraine prevention. The Sandor 2005 RCT cut attack frequency by 47.6% vs placebo — here's how to use it.

4 products rankedHeart health & energy

Magnesium

Limited Evidence

Magnesium oxide barely absorbs. AHS-endorsed migraine prevention needs a bioavailable form taken for 3–6 months. We rank glycinate, citrate, and bisglycinate by evidence.

4 products rankedSleep, stress & muscle health

Related goals in this cluster

Related angle: sleep and migraine prevention

This content is for educational purposes only and is not medical advice. These statements have not been evaluated by the FDA. Always consult your healthcare provider before starting any supplement.