Our Research
The Science Behind Our Rankings
Every recommendation on Healthy Aging Atlas is grounded in peer-reviewed clinical evidence. Here is how we evaluate, grade, and cite the research.
How We Evaluate Evidence
Our editorial team conducts systematic searches of PubMed and PubMed Central for each supplement we cover. We prioritize randomized controlled trials (RCTs), systematic reviews, and meta-analyses published in peer-reviewed journals.
Each supplement receives an evidence grade based on the volume, quality, and consistency of available human clinical data. We re-evaluate these grades quarterly as new research is published.
What Qualifies as Evidence
We hold ourselves to strict standards so that every claim on this site can be independently verified.
Human Clinical Trials
We only base efficacy claims on studies conducted in human participants. Animal studies provide context but never drive recommendations.
PubMed-Indexed Sources
Every cited study must be indexed in PubMed or PubMed Central, ensuring peer review and public accessibility.
Sample Size Transparency
We report the sample size (n=X) for every study cited, so readers can judge the statistical power of the evidence.
No Disease Claims
We never claim supplements treat, cure, or prevent any disease. We use structure/function language only, in compliance with FDA guidelines.
Browse by Evidence Level
Supplements are graded based on the strength of available human clinical evidence.
Strong Evidence
Multiple randomized controlled trials (RCTs) in humans, consistent results, published in peer-reviewed journals.
Moderate Evidence
At least one well-designed RCT or multiple observational studies with consistent findings.
Emerging Evidence
Preliminary human studies, strong mechanistic rationale, or early-stage clinical trials underway.
From Our Database (16 supplements)
How We Cite Research
Every health claim on Healthy Aging Atlas is backed by a specific study in the format: "Author et al., Journal, Year (n=X)"
PubMed-Indexed Only
We only cite studies indexed in PubMed or PubMed Central. No pre-print servers, no proprietary databases, no manufacturer-funded white papers without peer review.
Human Trials Required
Animal and in-vitro studies provide mechanistic context but are never used as the primary basis for dosage or efficacy claims. We require human clinical data.
Sample Sizes Noted
Every citation includes the sample size (n=X) so readers can assess the strength of the evidence themselves. A study with n=20 is very different from n=2,000.
Full Attribution
Citations follow the format: "Author et al., Journal Name, Year (n=X)". We link to the PubMed record whenever possible so you can verify the source.
Explore Our Standards
For a deeper look at how we build comparison pages, review our methodology and editorial policy.
Last updated: April 2026